Vical Updates Lead Vaccine Programs At NFID Vaccine Research Conference and Addresses Potential Response to H1N1 Swine Influenza Outbreak
On Tuesday April 28, 2009, 6:30 am EDT
BALTIMORE, April 28, 2009 (GLOBE NEWSWIRE) --
Vical Incorporated (NasdaqGM:VICL - News) today announced that the company's Vice President of Vaccine Research, Larry R. Smith, Ph.D., is presenting updates on the company's pandemic influenza and cytomegalovirus (CMV) vaccine programs at the 12th Annual Conference on Vaccine Research sponsored by the National Foundation for Infectious Diseases (Baltimore, April 27 - 29).
"Phase 1 Safety and Immunogenicity Results of Vaxfectin(r)-formulated Plasmid DNA Vaccines Encoding Influenza Virus H5 Hemaggluntinin,'' an oral presentation, summarizes results from the company's successful Phase 1 trial and future goals for its pandemic influenza DNA vaccine program. The double-blind, placebo-controlled, dose-escalation Phase 1 trial was conducted in approximately 100 healthy volunteers age 18 to 45 at three U.S. clinical sites. The trial was designed to assess safety and immunogenicity following vaccination, and to evaluate monovalent and trivalent Vaxfectin(r)-formulated H5N1 pandemic influenza DNA vaccines at various doses. The vaccines were safe and well tolerated in the trial, and induced antibody responses and T-cell responses against a matching strain of influenza virus, and cross-clade antibody responses against different strains.
The current public health emergency caused by outbreaks of H1N1 swine influenza highlights the need for a faster method to develop and produce vaccines. Vical's technology could produce a vaccine within six to nine weeks after the H1 hemagglutinin gene is sequenced. If the U.S. government or an international health agency issues a directive and provides the necessary resources, Vical is prepared to respond. In its broader pandemic influenza effort, Vical is currently exploring potential sources of funding for further development. The company's near-term goals are to confirm vaccine safety and immunogenicity in a larger number of subjects, optimize vaccine dose and adjuvant ratio, explore prime-boost regimens with different vaccines, and leverage the Phase 1 proof of concept for its DNA vaccine platform and Vaxfectin(r) adjuvant into additional indications.
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Vical Exploring Funding For Pandemic Flu Effort >VICL
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